Dr. Andrew Sawaya, an assistant professor of dermatology and cutaneous surgery at the University of Miami Miller School of Medicine, has been recognized with a prestigious grant from the Hidradenitis Suppurativa Foundation (HSF) for his outstanding work in translational research on this chronic inflammatory skin condition.
In an interview, Dr. Sawaya shared insights into his research journey and ongoing projects.
Q: What inspired you to pursue a career in research?
A: During my undergraduate years, I had the opportunity to volunteer in a lab at the University of Miami’s biophysics department. This experience ignited my passion for research, leading me to pursue a master’s degree at Johns Hopkins in biochemistry, where I delved into skin biology and its role in diseases like basal cell carcinoma. Upon returning to Miami, I joined Dr. Marjana Tomic-Canic’s lab and later pursued my Ph.D. under her mentorship, focusing on wound healing research. My post-doctoral work at the NIH explored wound healing from a different angle, studying the oral mucosa’s efficient healing process compared to chronic wounds.
Q: What are the key findings of your research on chronic wound healing and inflammation?
A: Our research challenges the notion of suppressed inflammation in chronic wounds. Unlike acute wounds, which exhibit an optimal inflammatory response that resolves efficiently, chronic wounds are characterized by lingering, suboptimal inflammation that hinders healing. We identified specific transcription factors and inflammatory cells involved in this process, particularly neutrophils and their role in NETosis, which is heightened in conditions like diabetic foot ulcers. Understanding these mechanisms informs potential therapeutic strategies targeting the inflammatory response in chronic wounds.
Q: How do you envision addressing suboptimal inflammation response in chronic wounds?
A: Contrary to conventional beliefs, stimulating a specific, localized inflammatory response is crucial for initiating the healing process in chronic wounds. By targeting this early phase of inflammation, we aim to guide wound healing towards a more effective trajectory.
Q: What are your current research focuses?
A: While continuing to investigate wound healing and tissue regeneration, my current focus includes exploring inflammatory diseases like hidradenitis suppurativa (HS), which shares common pathways with wound healing processes.
Q: What excites you about the future of your research?
A: I am eager to witness advancements in therapy development for chronic wounds, an area where existing treatments often fall short. Understanding why certain patients do not respond to therapies and why some chronic wounds spontaneously heal will be critical for future breakthroughs.
Q: What advice do you have for aspiring researchers?
A: Networking and finding genuine passion in your work are paramount. Collaborations across diverse specialties enhance research outcomes, offering varied perspectives and resources essential for progress in the field. Seek guidance from experienced mentors who can provide valuable insights and support.
Dr. Sawaya’s commitment to advancing translational research underscores the importance of innovative approaches in addressing complex dermatological conditions, offering hope for improved therapies and outcomes in the future.
